Why the study?
Although DAPT after PCI reduces MACE and stent thrombosis, optimal DAPT duration remains a concern in high bleeding risk patients.
Does short DAPT (1-3 months) reduce bleeding without increasing MACE compared to standard DAPT (6-12 months) in high bleeding risk patients undergoing PCI?
Population
7,242 HBR patients after PCI across five RCTs
Comparison
Short DAPT (1-3 months) vs standard DAPT (6-12 months)
Design
Systematic review and meta-analysis of RCTs
Follow-up
Median 12-months
Authors
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Supports short DAPT in high bleeding risk PCI to reduce bleeding; confirms MACE safety and may refine guidelines.
Does short DAPT (1-3 months) reduce bleeding without increasing MACE compared to standard DAPT (6-12 months) in high bleeding risk patients undergoing PCI?
In high bleeding risk patients undergoing PCI, 1-3 months of DAPT significantly reduces clinically-relevant bleeding compared to 6-12 months without increasing ischemic risk.
Bainey et al. (2023) studied this question.