Why the study?
Increased late sodium current plays an important pathophysiological role in cardiac diseases, including rhythm disorders, highlighting the need to evaluate its mechanisms and potential therapeutic inhibition.
Key points are not available for this paper at this time.
Design
Review
Answers are grounded in this paper and cite their sources.
This review summarizes the physiological and pathophysiological roles of the late sodium current (INa,late) in the heart and discusses its potential as a therapeutic target for antiarrhythmic agents.
Based on recent findings, an increased late sodium current (INa,late) plays an important pathophysiological role in cardiac diseases, including rhythm disorders. The article first describes what is INa,late and how it functions under physiological circumstances. Next, it shows the wide range of cellular mechanisms that can contribute to an increased INa,late in heart diseases, and also discusses how the upregulated INa,late can play a role in the generation of cardiac arrhythmias. The last part of the article is about INa,late inhibiting drugs as potential antiarrhythmic agents, based on experimental and preclinical data as well as in the light of clinical trials.
No takes yet. Share an insight, caveat, or question.
Horváth et al. (2020) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: