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August 1, 2014ESC Heart FailureOpen Access

The late sodium current in heart failure: pathophysiology and clinical relevance

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Authors

BHBalázs HorváthDBDonald M. Bers

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Overview

Supports INa,late as a therapeutic target in HF; leaves open clinical efficacy pending randomized trials.

Structured PICO

I
Intervention
INa,late-modifying drugs

This review highlights the pathophysiological role of the late sodium current in heart failure and the potential therapeutic value of its pharmacological modulation.

Cite This Study

Horváth et al. (2014) studied this question.

synapsesocial.com/papers/6a735db429b0f29a5dc67f31https://doi.org/10.1002/ehf.212003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its β1 subunit2009 · 54 citations
  2. 2CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction)2014 · 23 citations
  3. 3Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes2011 · 55 citations
  4. 4Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice2012 · 43 citations
  5. 5Ca <sup>2+</sup> /Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na <sup>+</sup> Channel in Cardiac Disease2012 · 122 citations