Key result
Modulation of the late sodium current (I(NaL)) represents a potential therapeutic strategy to correct abnormal repolarization and improve contractility in the failing heart.
Population
Failing myocardium and cardiomyocytes
Design
Review
Authors
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I(NaL) inhibition may warrant exploration as antiarrhythmic strategy; leaves open need for prospective clinical validation.
Targeting the late sodium current (I(NaL)) represents a potential therapeutic strategy to improve contractility and treat arrhythmias in heart failure.
Undrovinas et al. (2008) conducted a review in Heart failure. Late sodium current (I(NaL)) modulation was evaluated. Modulation of the late sodium current (I(NaL)) represents a potential therapeutic strategy to correct abnormal repolarization and improve contractility in the failing heart.
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