What is the clinical evidence from this study?

Study design: Review. Population: Arrhythmias. Intervention: Late INa.

What question did this study set out to answer?

The review aims to discuss the effects of increased late INa on cardiac electrical activity and arrhythmias.

June 10, 2013Cardiovascular ResearchOpen Access

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte

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Key result

An increase in late INa facilitates the formation of early and delayed afterpolarizations, triggered arrhythmias, and cellular Ca2+ loading, potentially leading to reentrant arrhythmias.

Population

Cardiomyocytes

Design

Review

Authors

JSJohn C. ShryockGilead Sciences (United States)YSYejia SongNanjing University of Aeronautics and Astronautics SRSridharan RajamaniJohnson & Johnson (United States)

Discussion

Member takes

Implication

May support late INa inhibition to suppress triggered arrhythmias; leaves open clinical translation in prospective trials.

Key Points

The review aims to discuss the effects of increased late INa on cardiac electrical activity and arrhythmias.
Review of existing literature regarding late INa in cardiomyocytes.
Discussion on the physiological roles of Na+ channels during action potentials.
Analysis of the impact of increased late INa on arrhythmogenesis.
Increased late INa prolongs action potential duration and enhances cellular Na+ loading.
Elevated late INa facilitates early and delayed afterpolarizations, leading to triggered arrhythmias.
Increased dispersion of repolarization time may result in reentrant arrhythmias.

Structured PICO

Population

Cardiomyocytes

Intervention

Increase of late INa (due to acquired conditions like heart failure or inherited Na+ channelopathies)

Outcome

Arrhythmogenic consequences (formation of early and delayed afterpolarizations, triggered arrhythmias, spontaneous diastolic depolarization, cellular Ca2+ loading, and reentrant arrhythmias)surrogate

Increased late sodium current (late INa) in cardiomyocytes contributes to arrhythmogenesis by prolonging action potential duration and increasing cellular sodium and calcium loading.

Cite This Study

Shryock et al. (2013) conducted a review in Arrhythmias. Late INa was evaluated. An increase in late INa facilitates the formation of early and delayed afterpolarizations, triggered arrhythmias, and cellular Ca2+ loading, potentially leading to reentrant arrhythmias.

synapsesocial.com/papers/6a1c73434d97451bbd2fc034 https://doi.org/10.1093/cvr/cvt145

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The arrhythmogenic consequences of increasing late INa in the cardiomyocyte

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider