Why the study?
Do slowly inactivating Na+ current blockers (TTX and R-56865) alleviate contractile dysfunction in isolated ischemic guinea pig hearts?
Population
Isolated Langendorff-perfused guinea pig hearts and papillary muscles subjected to 50 min of normothermic…
Comparison
Tetrodotoxin and R-56865 at concentrations of… vs Untreated ischemic control (implied)
Design
Preclinical
Follow-up
50 min of ischemia and 60 min of reperfusion
Authors
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Hypothesis-generating for Na+ current blockade in myocardial ischemia; leaves open translation to clinical cardioprotection.
Do slowly inactivating Na+ current blockers (TTX and R-56865) alleviate contractile dysfunction in isolated ischemic guinea pig hearts?
Low concentrations of slowly inactivating Na+ current blockers (TTX and R-56865) provide direct cardioprotective effects against ischemia-induced contractile dysfunction in isolated guinea pig hearts.
Grand et al. (1995) studied this question.
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