Why the study?
Does riluzole improve functional recovery and reduce intracellular calcium overload following ischaemia and reperfusion in isolated rat hearts and myocytes?
Population
Isolated, Langendorff perfused hearts from adult rats, and adult rat isolated myocytes subjected to…
Comparison
Riluzole (1-100 microM) vs Vehicle only (control)
Design
Preclinical
Follow-up
30 min global ischaemia followed by reperfusion
Authors
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Riluzole may protect against reperfusion injury in rat models; leaves open translation of persistent sodium current blockade to clinical cardioprotection.
Does riluzole improve functional recovery and reduce intracellular calcium overload following ischaemia and reperfusion in isolated rat hearts and myocytes?
Riluzole demonstrates cardioprotective effects against ischaemia-reperfusion injury in rat models by preferentially blocking the persistent sodium current.
Weiss et al. (2010) studied this question.
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