Key result
Reduction of late sodium current is expected to have therapeutic benefits in cardiovascular disease states such as ischaemia, where sodium-calcium overload is a major feature.
The late sodium current plays a key role in sodium-calcium overload and arrhythmogenesis, highlighting it as a potential therapeutic target in ischemic heart disease.
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May support late sodium current inhibition in ischemia; leaves open confirmation in prospective trials.
Late sodium current in cardiac cells is very small compared with the fast component, but as it flows throughout the action potential it may make a substantial contribution to sodium loading during each cardiac cycle. Late sodium current may contribute to triggering arrhythmia in two ways: by causing repolarisation failure (early after depolarisations); and by triggering late after depolarisations attributable to calcium oscillations in sodium-calcium overload conditions. Reduction of late sodium current would therefore be expected to have therapeutic benefits, particularly in disease states such as ischaemia in which sodium-calcium overload is a major feature.
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Denis Noble (2006) conducted a review in Cardiovascular disease, ischaemia, arrhythmia. Reduction of late sodium current was evaluated. Reduction of late sodium current is expected to have therapeutic benefits in cardiovascular disease states such as ischaemia, where sodium-calcium overload is a major feature.
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