Key result
Reduction of late sodium current is expected to have therapeutic benefits in cardiovascular disease states such as ischaemia, where sodium-calcium overload is a major feature.
Design
Review
Authors
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May support late sodium current inhibition in ischemia; leaves open confirmation in prospective trials.
The late sodium current plays a key role in sodium-calcium overload and arrhythmogenesis, highlighting it as a potential therapeutic target in ischemic heart disease.
Denis Noble (2006) conducted a review in Cardiovascular disease, ischaemia, arrhythmia. Reduction of late sodium current was evaluated. Reduction of late sodium current is expected to have therapeutic benefits in cardiovascular disease states such as ischaemia, where sodium-calcium overload is a major feature.
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