Key result
Altered intracellular sodium homeostasis and the slow inactivating sodium current play a key role in the pathophysiology of heart failure and the propensity for cardiac arrhythmias.
Design
Review
Authors
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Supports late sodium current research in heart failure; leaves open clinical benefits of targeted inhibitors pending trials.
This review highlights the pathophysiological importance of intracellular sodium homeostasis and the late sodium current in heart failure and arrhythmogenesis.
Maier et al. (2006) conducted a review in Heart failure. Altered intracellular sodium homeostasis and late sodium current was evaluated. Altered intracellular sodium homeostasis and the slow inactivating sodium current play a key role in the pathophysiology of heart failure and the propensity for cardiac arrhythmias.
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