Why the study?
Does oral CVS-1123 prevent coronary artery thrombosis in a conscious dog model of arterial wall injury?
Population
Conscious dogs with arterial wall injury induced by anodal current applied to the circumflex coronary artery
Comparison
Oral CVS-1123 vs Placebo containing diluent
Design
Preclinical
Follow-up
24 hours
Authors
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Supports further development of oral direct thrombin inhibitors for arterial thrombosis; leaves open translation from canine models to humans.
Does oral CVS-1123 prevent coronary artery thrombosis in a conscious dog model of arterial wall injury?
The direct thrombin inhibitor CVS-1123 is effective orally in reducing primary thrombus formation in a canine model of arterial wall injury.
Cousins et al. (1996) studied this question.
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