What question did this study set out to answer?

This research aims to understand how clot-bound thrombin is influenced by different inhibitors.

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors.

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This research aims to understand how clot-bound thrombin is influenced by different inhibitors.
Utilized human alpha-thrombin with specific activity of 2,850 U/mg.
Analyzed the protective effects of heparin-antithrombin III on thrombin.
Examined the susceptibility of thrombin to antithrombin III-independent inhibitors.
Clot-bound thrombin showed protection from heparin-antithrombin III inhibition.
Thrombin was found to be susceptible to inactivation by other types of inhibitors.

Experimental analysis explores thrombin's protection from heparin-antithrombin III and its inactivation by other inhibitors.

Reagents. Human a-thrombin, sp act 2,850 U/mg, was generously provided by Dr. J. Fenton II, New York State Department of

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Weitz et al. (1990) studied this question.

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Experimental analysis explores thrombin's protection from heparin-antithrombin III and its inactivation by other inhibitors.

Reagents. Human a-thrombin, sp act 2,850 U/mg, was generously provided by Dr. J. Fenton II, New York State Department of