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July 9, 2025npj Digital MedicineOpen Access

The overlooked role of exergames in cognitive-motor neurorehabilitation: a systematic review

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Why the study?

Do exergames improve motor and cognitive outcomes in adults with neurological conditions?

Comparison

Exergames vs control or baseline

Authors

MMMaria Grazia MaggioCentro Neurolesi Bonino PulejoFBFrancesca BaglioDon Carlo Gnocchi FoundationRMRaffaela MaioneCentro Neurolesi Bonino Pulejo

Discussion

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Implication

Supports exergames as feasible adjuncts in neurorehabilitation; confirms short-term motor-cognitive gains yet leaves optimal protocols and durability open.

Structured PICO

Do exergames improve motor and cognitive outcomes in adults with neurological conditions?

P
Population
Adults with neurological conditions (including mild cognitive impairment, mild neurocognitive disorder, mild-to-moderate dementia, chronic stroke, and Parkinson's disease) from 11 studies (8 RCTs, 2 feasibility studies, 1 secondary analysis).
I
Intervention
Exergame-based interventions (interactive video games combining physical activity with digital engagement).
C
Comparator
Conventional rehabilitation or no intervention.
O
Outcome
Motor and cognitive outcomes.

Exergames are a promising, feasible, and safe tool for cognitive-motor neurorehabilitation in adults with neurological conditions, though standardized protocols and long-term follow-up are needed.

Limitations

  • Heterogeneity in interventions, populations, and outcome measures limited comparability and generalizability
  • Absence of long-term follow-up
  • Small sample sizes and wide confidence intervals in some studies

Cite This Study

Maggio et al. (2025) studied this question.

synapsesocial.com/papers/6a19735ac05413006f585aebhttps://doi.org/10.1038/s41746-025-01843-4
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