Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference
Authors
Discussion
Loading...
Member takes
Implication
Consensus conference report reveals major barriers in clinical trials for kidney disease, highlighting strategies to streamline design and improve evidence.
Key Points
- To identify key barriers to conducting robust clinical trials in nephrology and outline actionable solutions for trial design and execution.
- Convened an international, multidisciplinary KDIGO controversies conference focused on clinical trials in nephrology.
- Conducted plenary presentations and breakout discussions to evaluate trial design, clinical endpoints, and trial conduct.
- Identified that most previous nephrology trials were underpowered to reliably detect realistic treatment effect sizes.
- Formulated consensus recommendations to streamline trial protocols, define standardized kidney and nonkidney outcomes, and reduce operational complexity.
Cite This Study
Baigent et al. (2017) studied this question.