Why the study?
Does impaired glucose metabolism affect nycthemeral blood pressure variability and arterial distensibility in untreated hypertensive patients with an elevated waist-hip ratio?
Does impaired glucose metabolism affect nycthemeral blood pressure variability and arterial distensibility in untreated hypertensive patients with an elevated waist-hip ratio?
In untreated hypertensive patients with central obesity, impaired glucose metabolism is associated with a loss of nocturnal blood pressure decline and altered arterial distensibility.
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Impaired glucose metabolism was associated with nondipping and higher PWV in centrally obese hypertensives; hypothesis-generating and requires prospective validation.
We studied the influence of glucose metabolism on the nycthemeral blood pressure (BP) pattern and arterial distensibility in 33 nontreated hypertensive patients, 45.6 +/- 8.5 years old, with elevated waist/hip ratio. All patients underwent an ambulatory BP monitoring, a pulse wave velocity (PWV) measurement, and an oral glucose tolerance test. The ratio of mean nocturnal:diurnal systolic BP (N/D ratio) was used to assess nycthemeral BP variability. N/D ratio correlated positively with PWV (r = 0.62; P < .01). When considered according to their glycemic status, N/D ratio and PWV were significantly higher (P < .05; P < .01) in diabetics and in glucose intolerants compared to patients with normal glucose levels. Our data indicate that the nycthemeral BP pattern was different according to the metabolic status. The loss of nocturnal decline in BP is associated with carbohydrate disturbances and reduced arterial stiffness.
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J. Ben Amar (1995) studied this question.
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