What does this research mean for the field?

Immunization with beta2-glycoprotein I (beta2GPI) promotes the development of early atherosclerosis and induces immune-mediated plaque maturation in LDL-receptor-deficient mice. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

September 15, 1998CirculationOpen Access

Induction of Early Atherosclerosis in LDL-Receptor–Deficient Mice Immunized With β ₂ -Glycoprotein I

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Why the study?

Does beta2GPI immunization increase atherosclerosis in LDL-receptor-deficient mice?

Structured PICO

Does beta2GPI immunization increase atherosclerosis in LDL-receptor-deficient mice?

Population

LDL-receptor-deficient (LDL-RD) mice (n=75 total across two experiments)

Intervention

Immunization with beta2-glycoprotein I (beta2GPI)

Comparator

Immunization with ovalbumin or nonimmunized controls

Outcome

Progression of atherosclerosis (mean aortic lesion size)surrogate

Immunization with beta2-glycoprotein I promotes early atherosclerosis in LDL-receptor-deficient mice, establishing a novel model for immune-mediated atherosclerosis.

Discussion

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Implication

Beta2GPI immunization accelerates atherosclerosis in this model; leaves open translation to human APS and cardiovascular risk.

Cite This Study

George et al. (1998) studied this question.

synapsesocial.com/papers/6a197a4e11f0614219d980bd https://doi.org/10.1161/01.cir.98.11.1108

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Induction of Early Atherosclerosis in LDL-Receptor–Deficient Mice Immunized With β ₂ -Glycoprotein I

Structured PICO

Discussion

Implication

Cite This Study

Induction of Early Atherosclerosis in LDL-Receptor–Deficient Mice Immunized With β ₂ -Glycoprotein I

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider