In canine pulmonary arterial cells, hypoxia triggers Ca2+ release from intracellular stores, inhibiting delayed rectifier K+ channels and causing membrane depolarization, a key early event in hypoxic pulmonary vasoconstriction.
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Leaves open translation to human hypoxic pulmonary vasoconstriction; extends mechanistic insights on calcium-potassium channel coupling in canine cells.
Post et al. (1995) studied this question.
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