Key result
Hypoxia blunts endothelium-dependent relaxation and augments porcine pulmonary artery contraction via EDRF modulation.
Population
Isolated porcine pulmonary artery rings (2 mm OD)
Comparison
Hypoxia and pretreatment with EDRF inhibitors… vs Normoxic conditions, intact endothelium, or no…
Design
Preclinical
Authors
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EDRF modulates hypoxic contraction without causing it in porcine arteries; leaves open its role in human pulmonary hypertension.
Suppression of basally released EDRF by hypoxia is not the cause of the contractile response to hypoxia, but EDRF modulates hypoxic contraction in porcine pulmonary arteries.
Ogata et al. (1992) studied Hypoxic pulmonary vasoconstriction. Hypoxia and EDRF inhibitors (methylene blue, oxyhemoglobin, L-NMMA) vs. Basal conditions / rings with intact endothelium was evaluated on Changes in isometric force (contractile response). Hypoxia significantly reduced endothelium-dependent relaxation and augmented contractile response, suggesting EDRF modulates hypoxic contraction of porcine pulmonary arteries in basal conditions.
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