October 1, 1993AJP Heart and Circulatory Physiology

Endothelium-derived contracting and relaxing factors contribute to hypoxic responses of pulmonary arteries

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Population

Porcine pulmonary artery rings (proximal and distal)

Comparison

Hypoxic challenge with or without L-NAME and… vs Baseline conditions and comparison between…

Design

Preclinical

Authors

KKKevin L. KovitzUniversity of Illinois Chicago TAT. D. AleskowitchJohns Hopkins University JSJ. T. SylvesterBioZyme (United States)

Discussion

Member takes

Implication

Caution against clinical extrapolation from porcine arteries; leaves open translation of segmental endothelium-derived responses to human hypoxia.

Structured PICO

Population

Porcine pulmonary artery rings (proximal and distal)

Intervention

Hypoxic challenge (moderate hypoxia at 10% and 4% O2, and anoxia at 0% O2) with or without L-NAME and indomethacin

Comparator

Baseline conditions (16% O2) and comparison between proximal and distal arteries

Outcome

Isometric tension (contraction or relaxation)surrogate

Hypoxia-induced responses in porcine pulmonary arteries vary by anatomical location and are mediated by a balance of endothelium-derived relaxing and contracting factors.

Cite This Study

Kovitz et al. (1993) studied this question.

synapsesocial.com/papers/6a8934f144eed047faeb1543 https://doi.org/10.1152/ajpheart.1993.265.4.h1139

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Implication

Caution against clinical extrapolation from porcine arteries; leaves open translation of segmental endothelium-derived responses to human hypoxia.

Endothelium-derived contracting and relaxing factors contribute to hypoxic responses of pulmonary arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelium-derived contracting and relaxing factors contribute to hypoxic responses of pulmonary arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider