Population
Isolated canine coronary arteries, femoral arteries, and femoral veins, with or without endothelium
Comparison
Hypoxia (10% or 5% O2) or anoxia (95% N2-5% CO2) vs Preparations without endothelium
Design
Preclinical
Authors
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Hypoxia-induced endothelial vasoconstriction may worsen coronary tone; leaves open the mediator's identity and human relevance.
Hypoxia and anoxia induce the release of a diffusible vasoconstrictor substance from the vascular endothelium, facilitating smooth muscle contraction.
Rubanyi et al. (1985) studied this question.
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