Key result
Removal of the endothelium abolished the contraction produced by hypoxia in sheep circumflex coronary artery rings, causing relaxation instead, and profoundly modified responsiveness to vasoactive agents.
Population
Isolated circumflex coronary artery rings (o.d. = 2.0-2.5 mm and o.d. = 0.6-1.3 mm) from sheep
Comparison
Endothelium removal and exposure to hypoxia or… vs Endothelium-intact artery rings and oxygenated…
Design
Preclinical
Authors
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Endothelial modulation of hypoxia in sheep coronary rings should not guide therapy; leaves open relevance to human coronary vasoreactivity.
The endothelium profoundly modifies the effect of hypoxia and pharmacological agents on the responsiveness of sheep isolated left circumflex coronary artery rings.
Kwan et al. (1989) studied None (healthy animal tissue). Endothelium removal and hypoxia vs. Endothelium-intact rings under oxygenated conditions was evaluated on Tension development in response to hypoxia and vasoactive agents. Removal of the endothelium abolished the contraction produced by hypoxia in sheep circumflex coronary artery rings, causing relaxation instead, and profoundly modified responsiveness to vasoactive agents.
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