Key result
Hypoxia-induced relaxations of rabbit thoracic aorta, lamb ductus arteriosus, and canine femoral artery were not dependent on an intact endothelium.
Population
Rings of canine femoral artery, rabbit thoracic aorta, and lamb ductus arteriosus
Comparison
Hypoxia in rings with intact endothelium vs Rings with damaged or absent endothelium
Design
Preclinical
Authors
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Endothelium-independent hypoxic relaxation in animal vessels; hypothesis-generating for smooth muscle oxygen sensing and should not change practice.
Hypoxia-induced relaxation of vascular smooth muscle does not depend on an intact endothelium, suggesting the oxygen sensor does not reside exclusively in endothelial cells.
Coburn et al. (1986) studied this question. Endothelium removal vs. Intact endothelium was evaluated on Hypoxia-induced relaxation of vascular smooth muscle. Hypoxia-induced relaxations of rabbit thoracic aorta, lamb ductus arteriosus, and canine femoral artery were not dependent on an intact endothelium.
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