Population
Helical strips cut from thoracic aortas, femoral and deep femoral arteries, and small arteries taken from…
Comparison
Stepwise reduction in oxygen pressure (hypoxia) vs Higher oxygen pressure levels
Design
Preclinical
Authors
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Hypoxia may impair arterial contractility at physiologic PO2; hypothesis-generating for resistance vessel dysfunction, requires human validation.
Vascular smooth muscle cells in both large and small arteries exhibit similar sensitivity to hypoxia, occurring at physiologic PO2 ranges for resistance vessels.
Chang et al. (1980) studied this question.
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