Key result
Hypoxia inhibited vascular smooth muscle myogenic activity and induced relaxation, likely by decreasing open Ca2+ channels and increasing Ca2+ channel inactivation.
Population
Vascular smooth muscle (VSM) from aorta and portal vein, including freshly dispersed single cells
Comparison
Low PO2 (hypoxia, 9.1-3.9 kPa) vs Normal PO2 (baseline conditions)
Design
Preclinical
Authors
Loading...
Should not alter clinical vascular management; leaves open translation of Ca2+ mechanisms to human studies.
Hypoxia inhibits vascular smooth muscle contractility by decreasing calcium channel permeability and altering calcium-activated potassium currents.
Soloviev et al. (1996) studied this question. Low PO2 (hypoxia) was evaluated on Ca2+ and K+ permeability and contractile responses. Hypoxia inhibited vascular smooth muscle myogenic activity and induced relaxation, likely by decreasing open Ca2+ channels and increasing Ca2+ channel inactivation.