Population
Smooth muscle cells enzymatically dispersed from rabbit cerebral, celiac, femoral, and main pulmonary…
Comparison
Reduction of O2 tension (PO2) / hypoxia vs Baseline/normal O2 tension
Design
Preclinical
Authors
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May contribute to hypoxic vasodilation; leaves open translation to human vessels.
Hypoxia inhibits L-type calcium channel activity in arterial smooth muscle cells, which may contribute to the hypoxic dilatation of systemic and main pulmonary arteries.
Franco‐Obregón et al. (1996) studied this question.
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