Population
Smooth muscle cells dispersed from conduit (proximal) and resistance (distal) rabbit pulmonary arteries
Comparison
Exposure to low PO2 (hypoxia) vs Baseline/normal PO2
Design
Preclinical
Authors
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Should not change clinical management of pulmonary hypertension; hypothesis-generating for myocyte heterogeneity in hypoxic vasoreactivity.
Calcium channels in rabbit pulmonary artery smooth muscle cells exhibit longitudinal differences in density and oxygen sensitivity, which may explain the differential reactivity to hypoxia (vasodilatation in conduit arteries and vasoconstriction in resistance vessels).
Franco‐Obregón et al. (1996) studied this question.
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