September 1, 1981AJP Heart and Circulatory Physiology

Tissue PO2 and arteriolar responses to metabolic stimuli during maturation of striated muscle

View Full Paper

Ask AI

Bookmark

Population

Hamsters aged 32, 60, and 80 days

Comparison

Superfusion of isolated cremaster muscle with a… vs Comparison across different age groups and…

Design

Preclinical

Authors

KPKenneth G. ProctorClinical Pharmacology of Miami DDDavid N. DamonUniversity of Virginia BDB. R. DulingUniversity of Virginia

Discussion

Member takes

Implication

Muscle PO2 dynamics differ by age under hypoxia in rodents; hypothesis-generating and leaves open human relevance.

Structured PICO

Population

Hamsters aged 32, 60, and 80 days

Intervention

Superfusion of isolated cremaster muscle with a solution equilibrated with 0, 5, or 10% O2 and stimulated to contract at 1 Hz

Comparator

Comparison across different age groups (32, 60, and 80 days) and different superfusate O2 concentrations

Outcome

Tissue O2 tension (PO2) and small arteriolar diameter at rest and during contractionsurrogate

Tissue PO2 at rest is maintained across age groups, likely due to an age-associated decrease in fiber O2 consumption, while younger animals show smaller PO2 decreases during contraction.

Cite This Study

Proctor et al. (1981) studied this question.

synapsesocial.com/papers/6a8b91c5f07ad6ed43b219fd https://doi.org/10.1152/ajpheart.1981.241.3.h325

View Full Paper

Ask AI

Bookmark

Tissue PO2 and arteriolar responses to metabolic stimuli during maturation of striated muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tissue PO2 and arteriolar responses to metabolic stimuli during maturation of striated muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider