Key result
Ageing in mice maintained arteriolar network architecture but impaired conducted vasodilatation (6 ± 1 µm in Old vs 10 ± 1 µm in Young, P<0.05) and attenuated postcontraction vasodilatation.
Population
83 C57BL6 male mice, divided into young (2-3 months), adult (12-14 months) and old (18-20 months)
Comparison
Ageing (Adult and Old groups) vs Young mice (2-3 months)
Design
Preclinical
Authors
Loading...
May contribute to age-related exercise intolerance via impaired microvascular function; leaves open translation to human skeletal muscle.
Ageing impairs conducted vasodilatation and attenuates postcontraction vasodilatation in skeletal muscle arterioles despite maintained network architecture, which may compromise exercise tolerance.
Bearden et al. (2004) studied Ageing (n=83). Ageing vs. Young mice was evaluated on Arteriolar network architecture and vasomotor responses. Ageing in mice maintained arteriolar network architecture but impaired conducted vasodilatation (6 ± 1 µm in Old vs 10 ± 1 µm in Young, P<0.05) and attenuated postcontraction vasodilatation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: