Population
Mice (tibialis muscle model)
Design
Preclinical
Follow-up
120 days
Authors
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Supports dual rAAV strategies for large genes via recombination; hypothesis-generating for clinical translation.
Concatamerization of AAV genomes in vivo occurs through intermolecular recombination, which may enable the delivery of large gene inserts using multiple independent rAAV vectors.
Yang et al. (1999) studied this question.
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