What does this research mean for the field?

Miyoshi myopathy is a heterogeneous, slowly progressive disorder characterized by initial calf weakness that progresses to proximal muscles, with disease progression driven by disease duration rather than age of onset. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1997BrainOpen Access

Miyoshi-type distal muscular dystrophy. Clinical spectrum in 24 Dutch patients

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Population

24 Dutch patients with Miyoshi-type distal muscular dystrophy

Design

Case_series

Authors

WLW.H.J.P. LinssenRadboud University Nijmegen

Discussion

Member takes

Implication

Alerts clinicians to duration-based progression risk in Miyoshi myopathy; leaves open genetic and geographic modifiers for prospective study.

Structured PICO

Population

24 Dutch patients with Miyoshi-type distal muscular dystrophy

Outcome

Clinical expression, natural history, muscle CT-scans, and muscle biopsy findings

Miyoshi myopathy is a heterogeneous, slowly progressive disorder where disease progression is related to disease duration rather than age of onset.

Cite This Study

W.H.J.P. Linssen (1997) studied this question.

synapsesocial.com/papers/6a19803fc3e09444f388db2c https://doi.org/10.1093/brain/120.11.1989

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Implication

Alerts clinicians to duration-based progression risk in Miyoshi myopathy; leaves open genetic and geographic modifiers for prospective study.