What does this research mean for the field?

[3H]Ketanserin is not strictly selective for serotonin 5-HT2 receptors, but also binds with high affinity to alpha-1-adrenergic receptors in the human brain cortex, demonstrating limited selectivity. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

January 1, 1987Journal of Cardiovascular Pharmacology

[3H]Ketanserin Labels Serotonin 5-HT2 and α1-Adrenergic Receptors in Human Brain Cortex

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Structured PICO

Population

Human brain cortex membranes, as well as rat and pig brain membranes

Intervention

[3H]ketanserin and [125I]BE 2254 binding assays

Outcome

Binding affinity and selectivity to serotonin 5-HT2 and alpha 1-adrenergic receptorssurrogate

Ketanserin possesses a limited degree of selectivity in human tissue, binding to both 5-HT2 and alpha 1-adrenergic receptors.

Discussion

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Implication

Questions ketanserin selectivity for 5-HT2 in human tissue; challenges consensus and leaves accurate labeling open.

Cite This Study

Hoyer et al. (1987) studied this question.

synapsesocial.com/papers/6a1983d1214a3f02e0d9783e https://doi.org/10.1097/00005344-198700103-00012

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[3H]Ketanserin Labels Serotonin 5-HT2 and α1-Adrenergic Receptors in Human Brain Cortex

Structured PICO

Discussion

Implication

Cite This Study

[3H]Ketanserin Labels Serotonin 5-HT2 and α1-Adrenergic Receptors in Human Brain Cortex

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider