Key result
Ketanserin significantly antagonized the alpha 1 receptor-mediated increase in arterial blood pressure after methoxamine treatment, indicating its antihypertensive action originates from peripheral alpha 1 receptor blockade.
Why the study?
Does ketanserin antagonise the alpha 1 receptor mediated increase in arterial blood pressure after treatment with methoxamine in healthy volunteers?
Population
n=5 healthy volunteers
Design
RCT, randomised crossover, double blind
Authors
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Supports mechanism-guided ketanserin use in hypertension; confirms peripheral alpha1 blockade as primary action via RCT.
RCT (n=5)
Double-blind
Randomized crossover
Does ketanserin antagonise the alpha 1 receptor mediated increase in arterial blood pressure after treatment with methoxamine in healthy volunteers?
The antihypertensive action of ketanserin in humans appears to be mediated by peripheral vascular alpha-1 receptor blockade.
Reimann et al. (1983) conducted an RCT in Healthy volunteers (n=5). Ketanserin was evaluated on Alpha 1 receptor mediated increase in arterial blood pressure after treatment with methoxamine. Ketanserin significantly antagonized the alpha 1 receptor-mediated increase in arterial blood pressure after methoxamine treatment, indicating its antihypertensive action originates from peripheral alpha 1 receptor blockade.
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