Key result
Ketanserin lowers blood pressure in rats by inhibiting sympathetic tone to the peripheral vasculature via alpha-1-adrenoceptor blockade rather than 5-HT receptor blockade.
Population
Normotensive Sprague-Dawley rats and conscious spontaneously hypertensive rats, as well as pithed rat…
Comparison
Ketanserin (0.0625 - 1.0 mg/kg intravenous) vs B.W. 501C67 (0.2 mg/kg) or baseline responses
Design
Preclinical
Authors
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Alpha-1 blockade, not 5-HT2 antagonism, drives ketanserin’s effect in rats; extends preclinical data but should not change practice.
The hypotensive action of ketanserin is primarily driven by alpha-1 adrenoceptor blockade rather than 5-HT2 receptor antagonism.
John R. Fozard (1982) studied Normotensive and spontaneously hypertensive rats. Ketanserin vs. B.W. 501C67 was evaluated on Blood pressure and heart rate. Ketanserin lowers blood pressure in rats by inhibiting sympathetic tone to the peripheral vasculature via alpha-1-adrenoceptor blockade rather than 5-HT receptor blockade.
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