Why the study?
Does ketanserin improve baroreflex sensitivity via central 5-HT2A receptors in spontaneously hypertensive rats?
Population
Conscious intact spontaneously hypertensive rats and SHR pretreated with anti-SERT-SAP
Comparison
Ketanserin (0.3 and 3.0 mg/kg, i.g.) vs Sham group / intact SHR vs toxin-pretreated SHR
Design
Preclinical
Follow-up
2 weeks after intracerebroventricular injection of the toxin
Authors
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Central 5-HT2A mediation of ketanserin’s BRS effects in SHR models; hypothesis-generating for human translation and selective serotonergic therapies.
Does ketanserin improve baroreflex sensitivity via central 5-HT2A receptors in spontaneously hypertensive rats?
The baroreflex sensitivity-enhancing effects of ketanserin are largely mediated by central 5-HT2A receptors, while its antihypertensive effect persists even after destruction of central serotonergic neurons.
Shen et al. (2007) studied this question.
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