Sex Differences in Cardiovascular Disease Risk Factor Prevalence, Morbidity, and Mortality in Colombia: Findings from the Prospective Urban Rural Epidemiology (PURE) Study
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Why the study?
Controversies exist regarding sex differences in cardiovascular risk factors and MACE, with most evidence originating from high-income countries.
Population
7,552 men and women aged 35-70 in Colombia
Comparison
Men vs women
Design
Prospective cohort study
Follow-up
Mean 12 years (SD 2.3)
Authors
Discussion
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Implication
Should not yet change risk stratification; leaves open mechanisms of sex disparities in MACE beyond traditional factors.
Structured PICO
P
Population
7,552 adults (women and men aged 35-70) from urban and rural communities in 11 departments of Colombia, mean age 50.7, 64.2% women.
O
Outcome
Time to event of the composite of MACE, including death, cardiovascular death, myocardial infarction, stroke, or heart failure, whichever occurred first.composite
In a Colombian cohort, men experienced a higher incidence of major adverse cardiovascular events than women despite having a lower overall burden of traditional risk factors, highlighting potential sex-based disparities in cardiovascular risk and outcomes.
Limitations
- Study population is limited to PURE-Colombia, which may not represent the diversity of sociocultural and demographic factors found in other regions
- Certain non-traditional and sociocultural cardiovascular risk factors might not have been collected
- Sixty-five percent of the population were women, affecting the sample's representativeness
- Some risk factors were self-reported, which may introduce bias
Cite This Study
López-López et al. (2024) studied this question.
Topics
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