February 1, 1990AJP Cell Physiology
Structure-activity relations of the cardiac gap junction channel
Population
Cardiac gap junction channels (specifically referencing rat heart models)
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May inform anesthetic effects on cardiac conduction; leaves open targeted modulation of gap junction open probability.
Structured PICO
P
Population
Cardiac gap junction channels (specifically referencing rat heart models)
I
Intervention
Various pharmacological and physiological gating stimuli (e.g., cytoplasmic acidification, halothane, heptanol, arachidonic acid, cyclic nucleotides, protein kinase C activators)
O
Outcome
Junctional conductance (gj) and channel gating mechanisms
This review outlines the structure, function, and pharmacological modulation of cardiac gap junction channels, laying the groundwork for potential therapeutic manipulation of cardiac conduction.
Cite This Study
Spray et al. (1990) studied this question.