Key result
Cardiac gap junction channels can be affected pharmacologically either acutely by modulating conductance or chronically by altering protein expression, with Cx43 and Cx40 differentially regulated.
Population
Various models including end-stage failing hearts, renovascular hypertension, atrial fibrillation, and…
Design
Review
Authors
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May inform connexin-targeted arrhythmia therapies; leaves open prospective clinical validation of selective agents.
Cardiac gap junction proteins connexin 43 and 40 can be differentially regulated by various pharmacological agents and disease states, which may impact the electrical syncytial properties of the heart.
Dhein et al. (2002) conducted a review in Cardiac gap junction regulation. Cardiac gap junction channels can be affected pharmacologically either acutely by modulating conductance or chronically by altering protein expression, with Cx43 and Cx40 differentially regulated.
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