Why the study?
Recent studies suggested poorer outcomes in ACS patients with concurrent schizophrenia compared with those without, but the degree of interplay remained poorly understood.
Does a concurrent diagnosis of schizophrenia worsen mortality and morbidity outcomes in patients with acute coronary syndrome?
Does a concurrent diagnosis of schizophrenia worsen mortality and morbidity outcomes in patients with acute coronary syndrome?
Patients with schizophrenia experience significantly worse mortality and morbidity outcomes following acute coronary syndrome compared to the general population, likely driven by a combination of biological, socioeconomic, and healthcare-related disparities.
May warrant closer post-ACS surveillance in schizophrenia; supports disparity-focused research but leaves causal mechanisms open.
Acute coronary syndrome (ACS) is a principal cause of mortality and morbidity worldwide. Recent studies have suggested poorer outcomes in ACS patients who have a concurrent diagnosis of schizophrenia as compared with those without. However, the degree of interplay between schizophrenia and ACS remains poorly understood. For this reason, we conducted a systematic review on ACS outcomes in patients with schizophrenia by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We collected relevant data from PubMed, Cochrane Library, PubMed central, Jisc Library Hub Discover, and the National Library of Medicine (NLM) and performed a thorough quality appraisal. Fourteen shortlisted, relevant studies were meticulously reviewed. Mortality and major adverse cardiac events (MACE), bleeding, and stroke were more prevalent in patients with a schizophrenia diagnosis compared to those without. Additionally, schizophrenia patients received suboptimal care and follow-up when compared to patients without a psychiatric diagnosis. Clinicians need to be aware that patients with schizophrenia have worse outcomes following ACS which may relate to biological, health care, or patient-related factors.
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Hannoodee et al. (2021) studied this question.
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