Key result
Schizophrenia in AMI linked to ~55% higher 1-year all-cause mortality.
Why the study?
Cardiovascular disease is a major cause of mortality in schizophrenia, and access to care after AMI is poor for these patients, necessitating understanding of revascularization impact on mortality.
Does a diagnosis of schizophrenia increase 1-year mortality in patients with acute myocardial infarction?
Population
108,610 incident AMI patients in Ontario between 2008 and 2015
Comparison
Patients with schizophrenia vs patients without schizophrenia
Design
Retrospective population-based cohort study
Follow-up
1 year
Authors
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Schizophrenia was associated with higher post-AMI mortality and lower revascularization rates; leaves open whether targeted access improvements would narrow survival gaps.
Cohort (n=108,610)
Does a diagnosis of schizophrenia increase 1-year mortality in patients with acute myocardial infarction?
Hazard Ratio: 1.55 (95% CI 1.37–1.77)
Patients with schizophrenia have higher mortality after AMI but derive similar survival benefits from revascularization, emphasizing the importance of equitable access to invasive management.
Hauck et al. (2020) conducted a cohort in Acute myocardial infarction (n=108,610). Schizophrenia vs. No schizophrenia was evaluated on All-cause mortality within 1 year (HR 1.55, 95% CI 1.37 to 1.77). Among patients with acute myocardial infarction, a diagnosis of schizophrenia was associated with increased 1-year all-cause mortality (HR 1.55; 95% CI 1.37-1.77).
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