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April 8, 2008Cardiovascular ResearchOpen Access

Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T

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Why the study?

Does adenovirus-mediated Hsp27 overexpression improve post-ischaemic contractile dysfunction in rat hearts subjected to ischaemia/reperfusion?

Population

Perfused rat hearts and cardiomyocytes subjected to ischaemia/reperfusion (I/R)

Comparison

Adenovirus-mediated Hsp27 overexpression vs Control

Design

Preclinical

Follow-up

30-min ischaemia / 30-min reperfusion

Authors

XLXiyuan LuShanghai Cancer InstituteLCLe ChenInstitute on GovernanceXCXiaolong CaiAnhui University of Science and Technology

Discussion

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Implication

Hypothesis-generating in rat I/R models; leaves open translation to human cardioprotection.

Structured PICO

Does adenovirus-mediated Hsp27 overexpression improve post-ischaemic contractile dysfunction in rat hearts subjected to ischaemia/reperfusion?

P
Population
Perfused rat hearts and cardiomyocytes subjected to ischaemia/reperfusion (I/R)
I
Intervention
Adenovirus-mediated Hsp27 overexpression
C
Comparator
Control (non-overexpressing hearts/cells subjected to I/R)
O
Outcome
Post-ischaemic contractile functionsurrogate

Hsp27 overexpression protects against ischaemia/reperfusion-induced cardiac dysfunction by stabilizing troponin I and T against proteolytic cleavage.

Cite This Study

Lu et al. (2008) studied this question.

synapsesocial.com/papers/6a199a1c43a2499ce8f64f4ehttps://doi.org/10.1093/cvr/cvn091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small Heat Shock Proteins and Protection Against Ischemic Injury in Cardiac Myocytes1997 · 345 citations
  2. 2Specific degradation of troponin T and I by μ-calpain and its modulation by substrate phosphorylation1995 · 167 citations
  3. 3Mutagenesis of cardiac troponin I. Role of the unique NH2-terminal peptide in myofilament activation.1994 · 81 citations
  4. 4Altered calcium sensitivity of isometric tension in myocyte-sized preparations of porcine postischemic stunned myocardium.1993 · 87 citations
  5. 5Intrinsic Myofilament Alterations Underlying the Decreased Contractility of Stunned Myocardium1996 · 157 citations