Why the study?
Does the level of inotropy affect the cardiac response (stroke volume and LV pressure pattern) to increased aortic pressure in dogs?
Does the level of inotropy affect the cardiac response (stroke volume and LV pressure pattern) to increased aortic pressure in dogs?
The cardiac response to increased aortic pressure (afterload) is dependent on the level of inotropy, with increased inotropy leading to increased stroke volume despite higher afterload.
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Animal data on inotropy-dependent afterload response warrant no clinical change; leaves open translation to human ventricular mechanics.
Bugge-Asperheim et al. (1969) studied this question.
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