Key result
Reducing aortic arch pressure increased the maximum rate of change of left ventricular pressure (dP/dt max) by an average of 43% in anaesthetized dogs.
Why the study?
Does changing aortic arch pressure alter the inotropic state of the left ventricle in anaesthetized dogs?
Does changing aortic arch pressure alter the inotropic state of the left ventricle in anaesthetized dogs?
Aortic arch baroreceptors may play an important role in controlling the inotropic state of the heart, as reducing aortic arch pressure significantly increases left ventricular dP/dt max.
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May indicate aortic baroreceptor control of LV inotropy in dogs; hypothesis-generating and leaves open human translation.
Hainsworth et al. (1972) studied this question. Changes in non-pulsatile pressure perfusing the vascularly isolated aortic arch was evaluated on Maximum rate of change of left ventricular pressure (dP/dt max). Reducing aortic arch pressure increased the maximum rate of change of left ventricular pressure (dP/dt max) by an average of 43% in anaesthetized dogs.
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