The Deep Genome Project

In vivo research is critical to the functional dissection of -organ systems and whole organism physiology, and laboratory mouse remains a quintessential animal model studying mammalian, especially human, pathobiology. by technological innovations in genome sequencing, and genome editing, phenotype analyses, and , in vivo analysis of gene function and dysfunction the mouse has delivered new understanding of the of disease and accelerated medical advances. , many significant hurdles have limited the elucidation mechanisms underlying both rare and complex, diseases, leaving significant gaps in our scientific . Future progress in developing a functionally genome map depends upon studies in model organisms, least the mouse. Further, recent advances in manipulation and in vivo, in vitro, and in silico phenotyping in the mouse make annotation of the majority of functional elements within the mammalian feasible. The implementation of a Deep Genome —to deliver the functional biological annotation of all human orthologous genomic elements in mice—is an essential executable strategy to transform our understanding genetic and genomic variation in human health and disease will catalyze delivery of the promised benefits of medicine to children and adults around the world.