Why the study?
Does mitochondrial aldehyde dehydrogenase (mtALDH) inhibition with cyanamide attenuate nitroglycerin-induced vasodilation in an intact canine model?
Population
14 healthy mongrel dogs (weight, 20 to 25 kg) in an intact canine model
Comparison
Cyanamide infusion followed by 1-mL bolus… vs Baseline hemodynamic and coronary blood flow…
Design
Preclinical
Follow-up
30 minutes after infusion
Authors
Loading...
Supports mtALDH dependence of GTN vasodilation in canines; hypothesis-generating with no clinical implications yet.
Does mitochondrial aldehyde dehydrogenase (mtALDH) inhibition with cyanamide attenuate nitroglycerin-induced vasodilation in an intact canine model?
Mitochondrial aldehyde dehydrogenase (mtALDH) is essential for the in vivo biotransformation and vasodilatory effects of nitroglycerin in coronary and systemic vessels.
Zhang et al. (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: