What does this research mean for the field?

In hyperinsulinemic, insulin-resistant obese Zucker rats, vascular tissue exhibits attenuated endothelin-1 peptide production but elevated ETA and ETB receptor levels, suggesting hyperinsulinemia upregulates these receptors to enhance vasoconstriction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 2000Cardiovascular ResearchOpen Access

Altered paracrine effect of endothelin in blood vessels of the hyperinsulinemic, insulin resistant obese Zucker rat

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Authors

SWShengjun WuFirst Affiliated Hospital Zhejiang University

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Implication

Attenuated ET-1 production with upregulated receptors in obese Zucker rats; leaves open whether hyperinsulinemia drives vascular dysfunction in metabolic disease.

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Cite This Study

Shengjun Wu (2000) studied this question.

synapsesocial.com/papers/6a19a6084b45427442ea8563 https://doi.org/10.1016/s0008-6363(99)00417-4

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Implication

Attenuated ET-1 production with upregulated receptors in obese Zucker rats; leaves open whether hyperinsulinemia drives vascular dysfunction in metabolic disease.

Altered paracrine effect of endothelin in blood vessels of the hyperinsulinemic, insulin resistant obese Zucker rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Altered paracrine effect of endothelin in blood vessels of the hyperinsulinemic, insulin resistant obese Zucker rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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