Why the study?
Does insulin attenuate vasoconstrictor responses to phenylephrine differently in aortae from lean versus obese Zucker rats?
Population
Thoracic aortae isolated from male 16-week-old lean and obese Zucker rats
Comparison
Insulin (0.1 mU/mL) incubation for 1 hour vs Absence of insulin (replicate helical strips)
Design
Preclinical
Authors
Loading...
Associates insulin resistance with vascular dysfunction in obesity; extends mechanistic understanding but leaves open clinical translation.
Does insulin attenuate vasoconstrictor responses to phenylephrine differently in aortae from lean versus obese Zucker rats?
Insulin resistance in obese Zucker rats is associated with a diminished ability of insulin to attenuate vasoconstrictor responses, potentially contributing to hypertension.
Zemel et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: