Impact of Transcatheter Edge-to-Edge Mitral Valve Repair on Atrial Functional Mitral Regurgitation from the GIOTTO Registry

Q: What does this research mean for the field?

In patients undergoing transcatheter edge-to-edge repair, atrial functional mitral regurgitation is associated with similar procedural success but significantly lower rates of cardiovascular death and heart failure compared to ischemic and nonischemic ventricular functional mitral regurgitation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Giulia Masiero; Carolina Montonati; Antonio Popolo Rubbio; Marianna Adamo; Carmelo Grasso; Paolo Denti; Arturo Giordano; Cosmo Godino; Antonio L. Bartorelli; Francesco De Felice; Annalisa Mongiardo; Ida Monteforte; Emmanuel Villa; Cristina Giannini; Corrado Tamburino; A. Petroni; Matteo Montorfano; Giulia Lorenzoni; Darío Gregori; Francesco Bedogni; Giuseppe Tarantini

doi:10.1016/j.amjcard.2023.11.007

Why the study?

Atrial functional mitral regurgitation has a unique pathophysiology that may lead to distinctive outcomes after transcatheter edge-to-edge repair compared with other etiologies.

Does transcatheter edge-to-edge repair result in different outcomes for atrial functional mitral regurgitation compared to ischemic or nonischemic ventricular functional mitral regurgitation?

Structured PICO

Does transcatheter edge-to-edge repair result in different outcomes for atrial functional mitral regurgitation compared to ischemic or nonischemic ventricular functional mitral regurgitation?

P

Population

1,153 patients with symptomatic functional mitral regurgitation (FMR) treated with MitraClip up to 2020, categorized as atrial FMR (n=71), ischemic FMR (n=541), and nonischemic ventricular FMR (n=541). Median age 73, 29% female, Italian registry.

I

Intervention

Transcatheter edge-to-edge repair (TEER) with the MitraClip system

C

Comparator

Ischemic FMR (iFMR) and nonischemic ventricular FMR (niFMR) etiologies

O

Outcome

Composite of cardiovascular death and hospitalization for heart failure up to the longest available follow-upcomposite

Limitations

Observational, nonprespecified analysis of a multicenter, single-arm, prospective registry
Unmeasured confounders
Lack of comparison with alternative management
Definition of aFMR based on recent consensus not clearly validated
Lack of core laboratory evaluation
Conclusion cannot be extended to newer MitraClip iterations and different TEER devices

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Masiero et al. (2023) studied this question.

synapsesocial.com/papers/6a19a9d905af093a17f6648d https://doi.org/10.1016/j.amjcard.2023.11.007

Topics

Mitral valve intervention

View Full Paper

Ask AI

Bookmark

Share

Impact of Transcatheter Edge-to-Edge Mitral Valve Repair on Atrial Functional Mitral Regurgitation from the GIOTTO Registry

Structured PICO

Limitations

Abstract

Discussion

Cite This Study

Topics

Impact of Transcatheter Edge-to-Edge Mitral Valve Repair on Atrial Functional Mitral Regurgitation from the GIOTTO Registry

Structured PICO

Limitations

Abstract

Discussion

Cite This Study

Keep reading

More related papers

More on Mitral valve intervention

More from The American Journal of Cardiology

Topics

Keep reading

More related papers

More on Mitral valve intervention

More from The American Journal of Cardiology