Key result
Progressive extramitral cardiac involvement is linked to ~86% higher mortality in significant SMR.
Why the study?
The prognostic implications of extramitral valve cardiac involvement groups in patients with moderate and severe secondary mitral regurgitation were unknown.
Does progressive extramitral valvular cardiac involvement predict all-cause mortality in patients with significant secondary mitral regurgitation?
Cohort (n=325)
Does progressive extramitral valvular cardiac involvement predict all-cause mortality in patients with significant secondary mitral regurgitation?
Echocardiographic staging of extramitral cardiac involvement provides prognostic value in patients with significant secondary mitral regurgitation, with right-sided involvement independently predicting higher all-cause mortality.
May support risk stratification in secondary MR; leaves open whether staging informs therapy selection.
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Singh et al. (2021) conducted a cohort in Significant secondary mitral regurgitation (n=325). Extramitral valve cardiac involvement (Groups 3 and 4) vs. Left ventricular or left atrial involvement (Groups 1 and 2) was evaluated on All-cause mortality (HR 1.857, 95% CI 1.145-3.012, p=0.012). Progressive extramitral valve cardiac involvement (groups 3 and 4) was independently associated with all-cause mortality in patients with significant secondary mitral regurgitation (HR 1.857; 95% CI 1.145-3.012; p=0.012 for group 4).
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