Key result
Under optimal guideline-based medical therapy, LVEF normalized to >50% at 6 months in 39% of STEMI patients who presented with a baseline LVEF <40%.
Why the study?
Does guideline-based medical therapy improve left ventricular ejection fraction recovery at 6 months in STEMI patients with baseline LVEF <40% treated with primary PCI?
Cohort (n=2,853)
Does guideline-based medical therapy improve left ventricular ejection fraction recovery at 6 months in STEMI patients with baseline LVEF <40% treated with primary PCI?
In STEMI patients with reduced LVEF (<40%) treated with primary PCI and guideline-directed medical therapy, nearly 40% experience full LVEF recovery (>50%) at 6 months.
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May inform expectations for recovery without changing practice; leaves open prospective validation of predictors.
Abou et al. (2018) conducted a cohort in ST-segment elevation myocardial infarction (STEMI) with reduced LVEF (n=2,853). Guideline-based medical therapy was evaluated on LVEF recovery (LVEF >50%) at 6 months follow-up. Under optimal guideline-based medical therapy, LVEF normalized to >50% at 6 months in 39% of STEMI patients who presented with a baseline LVEF <40%.
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