What question did this study set out to answer?

To determine how muscular reflexes and opposing arterial baroreflexes interact to regulate heart rate during isometric muscle contractions.

March 1, 1977Cardiovascular Research

Muscular reflex and baroreflex influences on heart rate during isometric contractions

View Full Paper

Ask AI

Bookmark

Why the study?

How do muscular reflex and baroreflex influence heart rate during isometric contractions in anaesthetised dogs?

Population

Anaesthetised dogs

Design

Preclinical

Authors

KSKeith StreatfeildJohn Hunter Hospital NDNatalie DavidsonUNSW Sydney DMD.I. McCloskeyNeuroscience Research Australia

Discussion

Member takes

Implication

Baroreflex blunting of HR response in canine isometric exercise warrants caution extrapolating to humans; leaves open mechanistic validation in conscious models.

Key Points

To determine how muscular reflexes and opposing arterial baroreflexes interact to regulate heart rate during isometric muscle contractions.
Induced isometric hindlimb contractions in anesthetized dogs via electrical stimulation of spinal ventral roots.
Measured systemic pressor reflexes and heart rate responses during induced contractions.
Isometric hindlimb contractions provoked marked systemic pressor increases accompanied by only modest heart rate elevations.
Primary cardioacceleratory reflexes originating from contracting skeletal muscle were partially counteracted and masked by concurrent baroreceptor-cardiodepressor reflexes.

Structured PICO

How do muscular reflex and baroreflex influence heart rate during isometric contractions in anaesthetised dogs?

Population

Anaesthetised dogs

Intervention

Isometric hindlimb contractions induced by stimulation of spinal ventral roots

Outcome

Heart rate and systemic pressor responsessurrogate

Heart rate increases during isometric contractions are blunted by opposing baroreceptor-cardiodepressor reflexes.

Cite This Study

Streatfeild et al. (1977) studied this question.

synapsesocial.com/papers/6a19b09f3f3ec013f0deed6d https://doi.org/10.1093/cvr/11.2.87

View Full Paper

Ask AI

Bookmark

Implication

Baroreflex blunting of HR response in canine isometric exercise warrants caution extrapolating to humans; leaves open mechanistic validation in conscious models.

Muscular reflex and baroreflex influences on heart rate during isometric contractions

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Muscular reflex and baroreflex influences on heart rate during isometric contractions

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider