What does this research mean for the field?

Isometric skeletal muscle contraction induces reflex increases in heart rate, arterial pressure, ventricular contractility, and respiratory volume via afferent pathways in the dorsal roots, with cardiovascular effects partially mediated by beta-adrenergic receptors. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1977AJP Heart and Circulatory Physiology

Reflex effects on circulation and respiration from contracting skeletal muscle

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Why the study?

Does induced isometric exercise reflexly alter cardiovascular and respiratory parameters in anesthetized cats?

Population

Anesthetized cats

Comparison

Isometric exercise induced by ventral root… vs Baseline resting state

Design

Preclinical

Authors

JMJ. H. MitchellTexas Health Harris Methodist Hospital Fort Worth WRWilliam C. ReardonThe University of Texas Southwestern Medical Center DMD.I. McCloskeyNeuroscience Research Australia

Discussion

Member takes

Implication

Hypothesis-generating in cats; does not support clinical translation or changes to human exercise management.

Structured PICO

Does induced isometric exercise reflexly alter cardiovascular and respiratory parameters in anesthetized cats?

Population

Anesthetized cats

Intervention

Isometric exercise induced by ventral root stimulation, with subsequent dorsal root sectioning or beta-adrenergic blockade (propranolol 1 mg/kg)

Comparator

Baseline resting state

Outcome

Changes in heart rate, mean arterial pressure, left ventricular dp/dt, and respiratory volumesurrogate

Isometric exercise induces reflex cardiovascular and respiratory changes originating from contracting skeletal muscle, partially mediated by cardiac beta-adrenergic receptors.

Cite This Study

Mitchell et al. (1977) studied this question.

synapsesocial.com/papers/6a1ddbc6871ff5209bef7723 https://doi.org/10.1152/ajpheart.1977.233.3.h374

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